In San Francisco, injuries again dominated the chatter as the 49ers head toward Week 1. Mac Jones sprained a knee in the latest preseason game and will sit this week, with Kyle Shanahan stressing it’s not expected to be a long-term issue and Week 1 remains the target. Dominick Puni is nursing a knee sprain and could miss multiple weeks, with a real possibility of missing the opener against Seattle. Depth pieces like Corey Kiner and Mykel Williams surfaced as potential swing players depending on practice recoveries.

The club also weighed season-opening roster decisions as Patrick Taylor Jr. went on IR and Nate Sudfeld was moved to clear a spot. Ben Bartch returned with a brace, Trent Williams and Matt Hennessy offered cautious optimism about blockers, and Renardo Green and Rencarno Stout were mentioned as calf and hamstring timelines linger. The combine of injuries underscores how Week 1 depth and special-teams contributions could swing fantasy value and roster edges forSF.