San Francisco’s wideout corps is being pushed to the limit by a wave of injuries, forcing fantasy managers to track timelines and potential opportunists. Brandon Aiyuk has the team’s clearest return window, hinting at Week 6 as a target while acknowledging the knee’s recovery remains fluid. The Niners also hope Malik Mustapha and Kurtis Rourke progress similarly, setting the stage for a midseason re-emergence. In the meantime, Jordan Watkins showed bursts but has now been sidelined by a high ankle sprain, leaving a quartet of veterans and a few untested pass-catchers to anchor Week 1 depth. Jauan Jennings remains a variable due to calf concerns, and Jacob Cowing plus Ricky Pearsall could play pivotal roles if the offense needs fresh options. Demarcus Robinson remains in limbo as the league’s ruling process unfolds. The situation underscores fantasy value fluctuations around a once-deep group and hints at a potential midseason shakeout once Aiyuk and co. are back near full strength.