New Orleans faces a tough test as Spencer Rattler and a battered offense host San Francisco. With Taysom Hill, Foster Moreau, Trevor Penning, and potentially Taliese Fuaga sidelined, the Saints must push a more efficient passing game and smarter play design to avoid an 0-2 start.

For fantasy managers, focus on Rashid Shaheed, Chris Olave, and Alvin Kamara as the trio most likely to produce targets and yards if the Saints unlock play-action and get the ball into space. San Francisco’s defense remains elite up front and in coverage, so protection and precision from Kellen Moore and Rattler will be pivotal for any redemption day in week 2.