Week 1 of the 2025 NFL season delivered more questions than answers for fantasy managers. Defenses dominated in many games, offenses looked slow adjusting to the new season, and Week 1 quirks compelled a cautious approach to streaming defenses. Denver’s defense stood out, while teams like the Titans and Colts showed offensive rust despite strong defensive stars elsewhere. Harold Fannin Jr. and Hollywood Brown lead the Week 2 waiver targets, with Cam Ward and Anthony Richardson among the rookies to monitor. Mahomes and the Chiefs remain a dominant threat, but Week 1 cues suggest careful, matchup-driven roster moves.