Jauan Jennings faces a Week 2 decision as he battles a shoulder injury that kept him sidelined at times in Week 1. With Brock Purdy out, the 49ers could lean on the run game and Christian McCaffrey, while Mac Jones starts at quarterback for the injury-plagued SF squad. If Jennings suits up, he could oscillate between a low-end flex and a risky upside play against a Saints secondary that's not impenetrable. If he sits, Ricky Pearsall and McCaffrey become the more dependable options, with Marquez Valdez-Scantling as a speculative depth piece.

The absence of George Kittle opens volume for others, but the QB switch may cap overall passing upside. Jennings’ value hinges on health and the Saints’ true pass defense; in a game likely dominated by the run, even a limited Jennings can carve out a usable role, though major upside isn’t guaranteed. Fantasy managers should weigh Jennings’ injury status heavily against the Week 2 risk/reward of this matchup.

Brock Purdy’s turf-toe injury sidelines the 49ers QB for up to five weeks, thrusting Mac Jones into Sunday’s matchup with New Orleans. Fantasy managers should scan the QB streamer list, with Daniel Jones, Trevor Lawrence, and even Aaron Rodgers cited as viable options in tougher spots.

Week 1’s injury avalanche continued with Austin Ekeler’s season-ending Achilles and George Kittle’s hamstring. Add in Xavier Worthy’s shoulder and Brock Bowers’s knee, and the waiver wire becomes a chessboard. Watch for sleepers like Harold Fannin Jr. and Emeka Egbuka to emerge for deeper leagues.