Mac Jones arrives in San Francisco with swagger that fits Shanahan’s offense, and the 49ers want to take over the Saints’ home field in Week 2. His locker-room energy and humor have teammates buying in as the offense seeks a steady, multi-faceted attack.

Demario Davis and New Orleans aim to slow Christian McCaffrey and pressure Jones, while San Francisco expects McCaffrey to anchor a heavy-volume game plan. Fantasy angles lean toward McCaffrey’s volume and Pearsall’s growing role, with a predicted low-scoring clash that tests both defenses and play-calling limits.

Steelers must clamp Seattle’s two-headed backfield, dial up pressure on Sam Darnold, and win third downs to keep drives off the field. After a rough showing vs Jets, Pittsburgh leans on T. J. Watt to spark the pass rush, while stout run defense and timely stops shape fantasy upside—Watt’s sack ceiling and Seahawks’ balanced attack.

From a fantasy lens, Watt becomes the primary catalyst if the Steelers can collapse the pocket. Seahawks RBs Charbonnet and Walker III are workload bets in a game-script that could tilt on efficiency in short-yardage and third-down scenarios. Monitor game flow and substitution patterns for optimal lineups.

Week 2 DFS spotlight centers on five RB matchups: Gibbs vs Bears, McCaffrey vs Saints, Conner vs Panthers, Hall vs Bills, Williams vs Cowboys. The focus is on game-script independent backs who can reach 15-20 touches regardless, a rarity in today’s NFL.

The Lions look to rebound at home while Chicago’s run defense isn’t as stout as last year. Arizona and San Francisco lean on their respective lead backs, with New York’s duo in a favorable grind. These spots fuel DFS lineups, season-long builds, and prop bets alike.