San Francisco’s preseason opener offered a clear snapshot of the 49ers’ rookie class in flux. Thirteen of the original seventeen rookies played, delivering a spectrum of outcomes from incomplete to standout. Mykel Williams was inactive with a knee issue, leaving edge-rep opportunities thin early. Alfred Collins and Nick Martin struggled to impact the game, while Upton Stout and Jordan Watkins flashed the most upside. Watkins snagged three of six targets for 56 yards, highlighted by a 50-yard grab that underscored potential early playing time. Contenders like Connor Colby flashed steady progress in pass protection, Junior Bergen provided a spark on special teams, and Marques Sigle looked the part of a developing starter in the secondary depth chart. The takeaway for fantasy: Watkins could press for early involvement, Kiner’s vision and stroke give him a roster case, and the 49ers’ late-rounds and undrafted group showed enough in flashes to keep a few on the radar for practice squads or later-season roles.

Other notes: Jordan James’ injury-impacted return suggests the depth at running back will be tested, while Kurtis Rourke remains on the non-football injury list, delaying a potential rookie quarterback path. CJ West’s nickel corner role remains a focal point as the defense builds interior pressure and coverage flexibility. In total, SF’s rookie performance laid a foundation of intrigue—enough to keep fantasy managers watching the next exhibition for real clues on playing time, role definition, and depth-chart movement as Week 1 approaches.