Week 3 pits undefeated San Francisco against Arizona with Kyler Murray shredding pressure through a 2.55s release and the Cardinals’ offense thriving on quick, accurate throws. San Francisco’s speed rush and Robert Saleh’s blitz variety loom large, while rookie Upton Stout flashed in Week 2 and could tip the edge. The game hinges on whether the 49ers can disrupt Murray or he continues to erase pressure with rapid decision-making.