Isaiah Prince left San Francisco's preseason finale with a left‑leg injury, casting doubt on the 49ers' early depth at offensive tackle as rosters tighten. With Prince potentially sidelined, Austen Pleasants, Spencer Burford, and Nick Zakelj figure to absorb extra work and shape the Week 1 line, which in turn could impact run blocks and pass protection for the backfield.

Burford’s versatility, Zakelj’s length, and Pleasants’ depth role become fantasy-relevant if Prince misses time, since any extended absence could shift linemen roles and influence SF’s early-season efficiency in both the run game and the pass game. Managers should watch Prince’s timeline and any IR chatter as cuts loom.