Week 2 outlook for San Francisco centers on Brock Purdy’s toe and shoulder injuries, with Shanahan calling Week 2 a long shot and hinting Purdy could miss multiple games. If Purdy sits, SF may turn to Mac Jones as a stopgap while they explore adding a third QB. Christian McCaffrey carries calf-day risk but remains the top fantasy asset if active; Williams, Bosa, and Jauan Jennings are limited or questionable. Depth options like Yetur Gross-Matos, Jordan Watkins, and Ben Bartch could gain value with added opportunities.