George Kittle’s hamstring injury in Week 1 robs San Francisco of a premier target, forcing Brock Purdy to navigate a reshaped passing game while SF’s training staff evaluates his status. Fred Warner and Trent Williams also exited early, amplifying concerns about both sides of the ball. With Deebo Samuel sidelined, Jauan Jennings, Ricky Pearsall, and Marquez Valdes-Scantling must rise quickly, and Purdy’s fantasy floor could tighten until the rookie receivers prove their Week 1 viability.

Kittle’s absence leaves a sizable void after a 2024 line of 78 catches, 1,106 yards, and 8 TDs. The 49ers will lean on Kittle’s supporting cast, and like Seattle’s defense, fantasy managers should monitor official injury updates closely. In the near term, Jennings, Pearsall, and MV-Scantling could carry a larger chunk of the aerial workload while Purdy stabilizes on quicker throws and yards-after-catch opportunities.