Valdes-Scantling's insider edge from six months with SF could unlock deeper shots against Seattle in Week 1, boosting SF's ceiling on the outside and giving Garoppolo-like comfort throws to stretch the field early.

ESPN highlighted Upton Stout as an under-the-radar rookie who, if healthy, should start in SF's nickel, potentially shifting matchup dynamics and elevating SF's mid-range attack as Seattle adjusts to a faster slot defender.

With Deebo Samuel moving to Washington and Brandon Aiyuk out until Week 6, Pearsall must lift, pushing Valdes-Scantling into a bigger role. SF's receiving corps thins quickly, so MVS and Pearsall become focal points early, shaping Week 1 targets and fantasy upside.

Week 1 against Seattle will test SF's WR depth, George Kittle usage, and a defense facing a familiar foe. The opener could be high-variance: big-play opportunities for Valdes-Scantling, value-filled targets for Pearsall, and a need for efficient play-action to spark the offense.