San Francisco’s preseason win over Los Angeles highlighted a wave of injuries to SF depth, led by Jakob Robinson’s forearm concern. With Jauan Jennings’ calf, Brayden Willis’ neck, and Jacob Cowing’s hamstring affecting Week 1 odds, fantasy managers should watch how the depth chart shifts behind Deebo Samuel and the tight end group. A handful of rookies—Jordan James, Tanner Mordecai, and others—could see increased opportunities as the 49ers navigate the early-season schedule.