Isaac Guerendo presents a compelling opportunity for fantasy football enthusiasts in 2025. Currently ranking as RB53, the San Francisco 49ers' running back demonstrated his potential last season, stepping in as the RB1 due to injuries to key players like Christian McCaffrey. With an impressive average of 5.0 yards per carry, Guerendo rushed for 420 yards and tallied four touchdowns during his rookie year. His ability to force missed tackles puts him among the top running backs, suggesting he could break out as a valuable asset if given the chance to start.

The 49ers' depth chart now positions Guerendo as the RB2 behind McCaffrey, whose injury history could open the door for extended playing time. If he can maintain his performance, he may quickly become a coveted target on the waiver wire, making him a sleeper pick worth considering during drafts.