Kittle sits just behind McBride and Bowers in top TE contention, offering elite upside in a tight end class that thins quickly. His weekly ceiling remains high in SF’s offense, making him a centerpiece for fantasy rosters seeking a steady TE1 with playoff upside.

Purdy is framed as more than a system quarterback, showcasing elite pre/post-snap diagnosis, throwing receivers open, and navigating Shanahan’s numbers-driven offense with poise. He’s efficient under pressure and excels at short-to-intermediate throws, making him a steady fantasy starter in SF’s high‐level system.

San Francisco provides the backdrop for Lance’s first field exposure against the team that drafted him, adding a chess-match element to the finale. Harbaugh’s return narrative bleeds into the matchup as a broader test of continuity for a franchise that prizes depth and precision. The result shapes the flow of the Chargers’ offense and defense into Week 1, with implications for roster construction and fantasy depth charts.

Moore’s move to SF injects fresh depth behind Aiyuk and Debo. Purdy’s leadership is central as SF reshapes the WR mix, potentially lifting Moore’s fantasy ceiling and altering Week 1 targets for Debo and Brandon Aiyuk.

Trent Williams headlines SF’s front, a cornerstone of one of the league’s most trusted pass-protecting units. The analysis underscores Williams’ veteran impact and the 49ers’ blocking culture, highlighting how protection quality translates into QB time and space for fantasy assets.